Why Is L-Citrulline Better Than L-Arginine for Nitric Oxide Support?
L-arginine is the direct substrate for nitric oxide synthase (NOS), the enzyme that produces nitric oxide. However, oral L-arginine supplementation is limited by significant first-pass metabolism in the intestinal wall and liver, where the enzyme arginase rapidly degrades L-arginine before it reaches systemic circulation. L-citrulline bypasses this limitation entirely because it is not a substrate for arginase. It is absorbed intact and converted to L-arginine in the kidneys, where it enters systemic circulation. Research comparing oral L-citrulline to oral L-arginine consistently shows that L-citrulline produces greater and more sustained increases in plasma L-arginine levels than equivalent doses of L-arginine itself. This is why L-citrulline is the preferred form for nitric oxide and circulation support.
Key Benefits
Circulation support L-citrulline supports the L-citrulline to L-arginine to nitric oxide pathway. Nitric oxide is a potent vasodilator that relaxes vascular smooth muscle, supporting healthy blood vessel tone and circulation. Health Canada licensed use under NPN 80139498.
Exercise performance support Supports nitric oxide production and healthy circulation to working muscles during exercise. Also supports urea cycle function and ammonia clearance, a key contributor to exercise-induced fatigue. Health Canada licensed use under NPN 80139498.
Superior bioavailability vs. L-arginine Bypasses first-pass arginase metabolism. Greater and more sustained plasma L-arginine elevation than equivalent oral L-arginine doses.
750mg free form L-citrulline per capsule 3000mg per daily dose of 4 capsules (2 capsules twice daily).
Health Canada licensed NPN 80139498. Made in Canada.
Vegan and non-GMO Gluten free, soy free. Hypromellose vegan capsule, no gelatin.
120 capsules 30 day supply at 4 capsules per day.